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Anticonvulsant activity of Morus alba and its effect on brain gamma-aminobutyric acid level in rats

1★, 2, 3, 3, 3, 2★ Corresponding author

  1. 1School of Pharmacy, Pacific University, Udaipur, Rajasthan, 2School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
  2. 2Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India
  3. 3School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia

CORRESPONDENCE

Gaurav Gupta

School of Pharmacy, Pacific University, Udaipur, Rajasthan

gauravpharma25@gmail.com

Volume 6, Issue 2 · pp. 188-190 · 2014 · DOI: 10.4103/0974-8490.129046

ABSTRACT

Sir, Morus alba (locally known as Tut, commonly known as white mulberry, Family: Moraceae) has been domesticated over thousands of years and adapted to many continents of Asia, Europe, North and South America and Africa with tropical, subtropical and temperate zones. As per Ayurveda, all parts of M. alba are medicinally important. In folk medicine, the plant is reportedly used in treating epileptic convulsions, mental illness, insomnia and hemicranias.[1] Number of active phytochemical constituents such as alkaloids,[2] flavonoids,[3] glycosides,[4,5] terpenoids,[6] steroids,[7] volatile oils, tannins,[8] has been reported from different parts of the plant. On the basis of reported traditional uses, we undertook the present study to determine the anticonvulsant activity of M. alba by using pentylenetetrazole (PTZ) and maximal electroshock (MES) ‑ induced convulsion models in rats. M. alba leaves were collected at the Campus of Siddhartha Institute of Pharmacy, Dehradun. The plants were identified and authenticated by Dr. Imran Kazmi, Department of Pharmacognosy, Siddhartha Institute of Pharmacy, Dehradun. After collection, the plant leaves which were air‑dried under shade were pulverized using a mechanical grinder. Methanol/water (1:1) solvent was used for the extraction of the air‑dried pulverized leaves (100 g) to obtain methanolic extract of M. alba (MEMA).

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    Gupta, G., Afzal, M., David, S. R., Verma, R., Candaswamy, M., & Anwar, F. (2014). Anticonvulsant activity of Morus alba and its effect on brain gamma-aminobutyric acid level in rats. Pharmacognosy Research, 6(2), 188-190. https://doi.org/10.4103/0974-8490.129046

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0