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Aphrodisiac activity of polyherbal formulation in experimental models on male rats

1★, 1, 2, 3, 4★ Corresponding author

  1. 1Departments of Pharmacology and Experimental Biology, Vedica College of Pharmacy, RKDF University, Bhopal
  2. 2Departments of Pharmacology and Toxicology, Institute of Pharmacy and Technology, Salipur
  3. 3Department of Pharmaceutical Chemistry, Jayamukhi Institute of Pharmaceutical science, Warangal
  4. 4Sri Sivani College of Pharmacy, Srikakulam, Andhra Pradesh, India

CORRESPONDENCE

Himanshu Bhusan Sahoo

Departments of Pharmacology and Experimental Biology, Vedica College of Pharmacy, RKDF University, Bhopal

bhusan.himanshu@yahoo.co.in

Volume 6, Issue 2 · pp. 120-126 · 2014 · DOI: 10.4103/0974-8490.129029

ABSTRACT

To investigate the aphrodisiac potential of polyherbal formulations prepared from different parts of Tribulus terrestris, Curculigo orchioides, Allium tuberosum, Cucurbita pepo, Elephant creeper, Mucuna pruriens, and Terminalia catappa in Albino rats in specified ratio as suspension. The different concentrations of prepared polyherbal formulations i.e. 150, 300, and 600 mg/kg and sildenafil citrate as standard (5 mg/kg) and vehicle (control) were administered orally to rats (n = 6 animals per group) for 3 weeks. Mating behavior parameters in male rats was monitored in first week and third week week of treatment pairing with receptive females. After termination of drug treatment, the mating performance, hormonal analysis, sperm count, and testes-body weight ratio were also evaluated. The polyherbal formulation showed a significant increase in mating behavior as well as mating performance, serum hormonal levels, sperm count, and testes-body weight ratio with dose-dependent relationship as compared to vehicle control. But the dose of 600 mg/kg of polyherbal formulation assumes closer resemblance of above parameters with the standard used. The results of the study strongly suggest that the polyherbal formulations have a good aphrodisiac activity on rats in the above experimental models, which may be an alternative weapon for various sexual dysfunctions in future.

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    Sahoo, H. B., Nandy, S., Senapati, A. K., Sarangi, S. P., & Sahoo, S. K. (2014). Aphrodisiac activity of polyherbal formulation in experimental models on male rats. Pharmacognosy Research, 6(2), 120-126. https://doi.org/10.4103/0974-8490.129029

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0