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Evaluation of antiepileptic activity of chloroform extract of Acalypha fruticosa in mice

1, 2★★ Corresponding author

  1. 1Department of Pharmacognosy and Phytochemistry, Vaagdevi College of Pharmacy, Hanamkonda
  2. 2Department of Chemistry, Institute of Pharmaceutical Technology, Tirupati, Andhra Pradesh, India

CORRESPONDENCE

Sreedevi Adikay

Department of Chemistry, Institute of Pharmaceutical Technology, Tirupati, Andhra Pradesh, India

sridevitirupati@rediffmail.com

Volume 6, Issue 2 · pp. 108-112 · 2014 · DOI: 10.4103/0974-8490.128970

ABSTRACT

The aim of the present study is to evaluate the antiepileptic activity of chloroform extract of aerial parts of Acalypha fruticosa in mice. The antiepileptic activity of chloroform extract of A. fruticosa at the doses of 30, 100 and 300 mg/kg, p.o. was evaluated by maximum electroshock (MES), pentylenetetrazole (PTZ) and isoniazid (INH)-induced convulsions in mice. Statistical analysis was carried out by one-way analysis of variance followed by Dunnett’s test. In MES method, the chloroform extract significantly protected the mice from convulsions induced by electroshock method in a dose-dependent manner and exhibited more activity at the dose of 300 mg/kg when compared with diazepam treated animals. In PTZ method, the extract inhibited convulsions in mice potent than phenobarbitone sodium. In INH method, it delayed the latency of convulsions in mice in a dose-dependent manner but failed to protect the mice against mortality. The chloroform extract exhibited significant and dose-dependent antiepileptic activity, which may be due to the presence of antioxidant principles like flavanoids.

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    Govindu, S., & Adikay, S. (2014). Evaluation of antiepileptic activity of chloroform extract of Acalypha fruticosa in mice. Pharmacognosy Research, 6(2), 108-112. https://doi.org/10.4103/0974-8490.128970

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0