Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

Inhibitory effects by ayurvedic plants on prostate enlargement induced in rats

1★, 2, 1★ Corresponding author

  1. 1Department of Pharmacognosy, TVES’s Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Maharashtra
  2. 2Department of Pharmacognosy, Rajgad Dyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra, India

CORRESPONDENCE

Rahul K. Dumbre

Department of Pharmacognosy, TVES’s Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Maharashtra

rahuldumbre@hotmail.com

Volume 6, Issue 2 · pp. 127-132 · 2014 · DOI: 10.4103/0974-8490.129031

ABSTRACT

Ayurveda recommends several plants and plant preparation for conditions of urogenital disorders as per its principles.Objectives: Ayurvedic plants Tamala (Cinnamomum tamala); Daruhalad (Berberis aristata); Ativish (Aconitum heterophyllum) were studied for mechanisms of prostatic hyperplasia induced in rats. Prostatic enlargement was induced in castrated rats by testosterone injection s.c. for 21 days and simultaneously plants were dosed orally daily. On day 22 rats were sacrificed and prostate was removed; weight and volume of prostate was measured; histopathology performed. Inflammation was induced by injecting carrageenan in rat hind paw and inhibition was studied by measuring rat paw oedema at different time points. Tamala showed significant effect where it reduced prostatic enlargement and improved hyperplastic changes, while Daruhalad and Ativisha did not show any significant effect. All of them showed mild to moderate anti-inflammatory activity. Study concludes that Tamala may benefit in prostate disorder by virtue of inhibition of androgen mechanisms in prostate and modulating inflammatory mediators in prostate. Daruhalad and Ativisha did not show any effect in this model of prostate enlargement while the anti-inflammatory effect may propose one of the useful properties when included in various formulations.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Dumbre, R. K., Kamble, M. B., & Patil, V. R. (2014). Inhibitory effects by ayurvedic plants on prostate enlargement induced in rats. Pharmacognosy Research, 6(2), 127-132. https://doi.org/10.4103/0974-8490.129031

    Copyright and licence

    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0