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Colon-targeted quercetin delivery using natural polymer to enhance its bioavailability

1★, 1, 2, 3, 3★ Corresponding author

  1. 1B. R. Nahata College of Pharmacy, BRNSS-Contract Research Center, Mhow-Neemuch Road, Mandsaur, Madhya Pradesh
  2. 2Seth G L Bihani College of Technical Education, Sri Ganganagar, India
  3. 3Unijules Life Science Ltd. and Associated Companies, Nagpur

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Anil Singhal

B. R. Nahata College of Pharmacy, BRNSS-Contract Research Center, Mhow-Neemuch Road, Mandsaur, Madhya Pradesh

Volume 3, Issue 1 · pp. 35-39 · 2011 · DOI: 10.4103/0974-8490.79113

ABSTRACT

The aim of the present study is to develop a polymer (Guar Gum)-based matrix tablet (using quercetin as a model drug) with sufficient mechanical strength, and promising in vitro mouth-to- colon release profile. By definition, an oral colonic delivery system should retard drug release in the stomach and small intestine, and allow complete release in the colon. By drug delivery to the colon would therefore ensure direct treatment at the disease site, lower dosing, and fewer systemic side effects. Quercetin is antioxidant in nature and used to treat colon cancer, but they have poor absorption in the upper part of the gastrointestinal tract (GIT). As a site for drug delivery, the colon offers a near neutral pH, reduced digestive enzymatic activity, a long transit time, and an increased responsiveness to absorption enhancers. By achieving a colon-targeted drug delivery system, the absorption of quercetin may be increased, which leads to better bioactivity in fewer doses.

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    Singhal, A., Jain, H., Singhal, V., Elias, E. J., & Showkat, A. (2011). Colon-targeted quercetin delivery using natural polymer to enhance its bioavailability. Pharmacognosy Research, 3(1), 35-39. https://doi.org/10.4103/0974-8490.79113

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    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0