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Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals

1, 2, 3, 3★, 3, 2★ Corresponding author

  1. 1Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria and Division of Pharmacology, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
  2. 2Division of Pharmacology, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
  3. 3Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria

CORRESPONDENCE

Dr. A. A. Oyagbemi

Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria

ademolaoyagbemi@yahoo.com

Volume 3, Issue 1 · pp. 2-8 · 2011 · DOI: 10.4103/0974-8490.79108

ABSTRACT

The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB) whole fruit in laboratory rats. The anti-ulcer property of the ethanolic extract of the whole fruit of Lagenaria breviflora (LB) was assessed using the cold-restraint stress-induced (CRU) gastric ulcer, pyloric ligation-induced (PL) gastric ulcer, aspirin-induced (ASP) gastric ulcer and alcohol-induced (AL) gastric ulcer models. The scavenging activity of the LB extract was examined with 1, 1-diphenyl-2-picryl-hydrazyl (DPPH), Nitric oxide, Hydroxyl radical and Superoxide anion scavenging models. EELB (50, 100, 150 and 200 mg/kg, b.w.) protected against the CRU gastric ulcer dose dependently. Similarly, 150 mg/kg b.w. of the LB extract protected against the PL gastric ulcer, ASP gastric ulcer and AL gastric ulcer and was comparable to omeprazole (10 mg/kg b.w.) or Suscralfate (500 mg/kg b.w.), respectively. The in vitro antioxidant activity of LB was demonstrated by its ability to quench free radicals generated by nitric oxide and superoxide anion with a concomitant scavenging potential against DPPH-induced radical formation. Taken together, the study showed that the whole fruit extract possess potent anti-ulcer and antioxidant activities.

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    Onasanwo, S. A., Singh, N., Saba, A. B., Oyagbemi, A. A., Oridupa, O. A., & Palit, G. (2011). Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals. Pharmacognosy Research, 3(1), 2-8. https://doi.org/10.4103/0974-8490.79108

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    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0