Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

The study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats

1★, 1, 2★ Corresponding author

  1. 1T.V.M. College of Pharmacy, Gandhi Nagar, Bellary-583 103
  2. 2Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Sector-III, Pushp Vihar, New Delhi-110 017, India

CORRESPONDENCE

H. Kirana

T.V.M. College of Pharmacy, Gandhi Nagar, Bellary-583 103

Volume 3, Issue 1 · pp. 30-34 · 2011 · DOI: 10.4103/0974-8490.79112

ABSTRACT

Chronic systemic inflammation is an early process in pathogenesis of type 2 diabetes. Hence the present study was aimed to investigate the effect of traditionally known plant Ficus religiosa on elevated glucose and inflammatory marker namely tumor necrosis factor (TNF)-α in type 2 diabetic rats. Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rat model. Aqueous extract of F. religiosa at a dose of 100 and 200 mg/ kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose and TNF-α in serum were analyzed. Aqueous extract of F. religiosa at both dose levels i.e., 100 and 200 mg/kg decreased the elevated glucose and TNF-α in type 2 diabetic rats. The extract at 200 mg/kg had more pronounced effect. Modulation of cytokine TNF-α by the aqueous extract of F. religiosa indicates that the anti-inflammatory and immunomodulatory property of the plant is related with its potential anti-diabetic activity.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Kirana, H., Jali, M. V., & Srinivasan, B. P. (2011). The study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats. Pharmacognosy Research, 3(1), 30-34. https://doi.org/10.4103/0974-8490.79112

    Copyright and licence

    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0