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Ameliorative effect of Phytocee™ Cool against carbon tetrachloride-induced oxidative stress

1★, 1, 2, 3, 3, 3★ Corresponding author

  1. 1Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala
  2. 2Pookode, Wayanad, Kerala
  3. 3Department of Pharmacology and Toxicology, R&D Centre, Natural Remedies, Bangalore, Karnataka, India

CORRESPONDENCE

Joshua Allan Joseph

Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala

jjoshuaallan@gmail.com

Volume 6, Issue 4 · pp. 320-325 · 2014 · DOI: 10.4103/0974-8490.138284

ABSTRACT

Antioxidants from natural sources have a major role in reversing the effects of oxidative stress and promoting health, growth and productivity in animals. This study was undertaken to investigate the possible antioxidant activity and hepatoprotective effects of Phytocee™ Cool on carbon tetrachloride (CCl4) induced oxidative stress and liver damage in rats. Animals were pretreated with Phytocee™ Cool for 10 days and were challenged with CCl4 (1:1 v/v) in olive oil on the 10th day. After 24 h of CCl4 administration blood was collected and markers of hepatocellular damage aspartate aminotransferase (AST), alanine aminotransferase (ALT) were evaluated. Rats were sacrificed and oxidative stress in liver was estimated using malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase. CCl4 caused a significant increase in serum AST, ALT, hepatic MDA and GSH levels, whereas the SOD and catalase activities were decreased. Phytocee™ Cool pretreatment attenuated the MDA, AST ALT levels and increased the activities of SOD and catalase. Phytocee™ Cool demonstrated antioxidant potential and hepatoprotective effects and plausibly be used in the amelioration of oxidative stress.

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    Joseph, J. A., Ayyappan, U. P. T., Sasidharan, S. R., Mutyala, S., Goudar, K. S., & Agarwal, A. (2014). Ameliorative effect of Phytocee™ Cool against carbon tetrachloride-induced oxidative stress. Pharmacognosy Research, 6(4), 320-325. https://doi.org/10.4103/0974-8490.138284

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0