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Pharmacological Screening of Trachyspermum ammi for Antihyperlipidemic Activity in Triton X‑100 Induced Hyperlipidemia Rat Model

1★, 1, 2, 1★ Corresponding author

  1. 1Faculty of Pharmaceutical Sciences, Government College University, Faisalabad.
  2. 2Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Pakistan

CORRESPONDENCE

Uzma Saleem

Faculty of Pharmaceutical Sciences, Government College University, Faisalabad.

Volume 9, Issue 5s · pp. s34-s40 · 2017 · DOI: 10.4103/pr.pr_37_17

ABSTRACT

Background: Mortality rate is increasing due to cardiovascular problems throughout the world. These cardiac problems are directly associated with dyslipidemia.Aim: The aim of this study was to evaluate the antihyperlipidemic effect of aqueous extract and methanol extract of Trachyspermum ammi at 1 g/kg, 3 g/kg, and 5 g/kg dose levels in rats.Materials and Methods: For this purpose, 45 male albino rats were used and randomly divided into nine equal groups (n = 5). The lipid levels were increased after 24 h of single intraperitoneal injection of Triton X‑100 (100 mg/kg) in rats. Aqueous and methanol extracts equivalent to 1 g/kg, 3 g/kg, and 5 g/kg were administered orally to the rats for 21 days. Atorvastatin (10 mg/kg) was used as standard drug. Blood samples were collected at 0, 2nd, 9th, 16th, and 23rd day by a direct cardiac puncture in Vacuette® heparin tubes. Serum was separated and then analyzed for lipid profile, liver function test (LFT), and renal function test (RFT) using standard diagnostic kits.Results: Results showed that extracts at 3 g/kg and 5 g/kg decreased the levels of total cholesterol, triglyceride, and low‑density lipoprotein and increased high‑density lipoprotein concentration in serum. T. ammialso decreased LFT and RFT parameters at the end of the study.Conclusion: T. ammipossessed antioxidant and antihyperlipidemic activities along with hepato‑ and nephro‑protective effects.

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    Saleem, U., Riaz, S., Ahmad, B., & Saleem, M. (2017). Pharmacological Screening of Trachyspermum ammi for Antihyperlipidemic Activity in Triton X‑100 Induced Hyperlipidemia Rat Model. Pharmacognosy Research, 9(5s), s34-s40. https://doi.org/10.4103/pr.pr_37_17

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    © 2017 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0