Communication · Volume 9, Issue 3 · pp. 301-303
Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum
Kannan Vadivel1, Gollapudi Sandeep Kumar1, Sitty Manohar Babu1
- 1Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA.
Abstract
Objective: The present study has been undertaken with the main objective of evaluating the aqueous extract of flowers of Muntingia calabura for antispasmodic activity on isolated rabbit’s jejunum.Materials and Methods: The study was carried out on isolated rabbit’s jejunum preparations. The aqueous extract of flowers of M. calabura was applied in different doses by cumulative manner without washing the tissue. Spontaneous contractions abolished by the extract were recorded.Results: In isolated rabbit’s jejunum preparation, the flower extract of M. calabura inhibited the spontaneous contractions in a concentration‑dependent manner with IC100 value of 36 ± 3.02 μg/mL, which is potent than the standard drug verapamil with IC100 value of 40 ± 1.02 μg/mL on the rabbit’s jejunum.Conclusion: The aqueous extract of flowers of M. calabura exhibits significant dose‑dependent relaxations of spontaneous contractions in isolated rabbit’s jejunum preparations.
Keywords: Ex vivo antispasmodic activity; IC100 values; Muntingia calabura; Verapamil
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