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Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum

1, 1, 1

  1. 1Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA.

CORRESPONDENCE

Kannan Vadivel

Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA.

vadivelshiva@yahoo.co.in

Volume 9, Issue 3 · pp. 301-303 · 2017 · DOI: 10.4103/pr.pr_99_16

ABSTRACT

Objective: The present study has been undertaken with the main objective of evaluating the aqueous extract of flowers of Muntingia calabura for antispasmodic activity on isolated rabbit’s jejunum.Materials and Methods: The study was carried out on isolated rabbit’s jejunum preparations. The aqueous extract of flowers of M. calabura was applied in different doses by cumulative manner without washing the tissue. Spontaneous contractions abolished by the extract were recorded.Results: In isolated rabbit’s jejunum preparation, the flower extract of M. calabura inhibited the spontaneous contractions in a concentration‑dependent manner with IC100 value of 36 ± 3.02 μg/mL, which is potent than the standard drug verapamil with IC100 value of 40 ± 1.02 μg/mL on the rabbit’s jejunum.Conclusion: The aqueous extract of flowers of M. calabura exhibits significant dose‑dependent relaxations of spontaneous contractions in isolated rabbit’s jejunum preparations.

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    Vadivel, K., Kumar, G. S., & Babu, S. M. (2017). Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum. Pharmacognosy Research, 9(3), 301-303. https://doi.org/10.4103/pr.pr_99_16

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    © 2017 Author(s)

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