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Effect of Musa sapientum Stem Extract on Animal Models of Depression

1, 1, 1★, 1, 2, 1★ Corresponding author

  1. 1Department of Pharmacology, SMS&R, Sharda University, Greater Noida, NCR, Uttar Pradesh
  2. 2Department of Biochemistry, University College of Medical Sciences, New Delhi, India

CORRESPONDENCE

Ashok Kumar Dubey

Department of Pharmacology, SMS&R, Sharda University, Greater Noida, NCR, Uttar Pradesh

ak.dubey@sharda.ac.in

Volume 8, Issue 4 · pp. 249-252 · 2016 · DOI: 10.4103/0974-8490.188876

ABSTRACT

Musa sapientum, the banana plant, has shown to possess antioxidant activity in previous studies. Oxidative stress has been linked to the pathogenesis of major depressive disorder (MDD) with evidence of increased serum levels of oxidative stress biomarkers in MDD patients. The present study aimed to evaluate the antidepressant activity of M. sapientum stem extract (MSSE) in experimental models in mice. Forced swim test (FST) and tail suspension test (TST) were carried out in five different groups (n = 6/ group) of mice. The vehicle, standard drug, and the three test groups were orally administered distilled water (10 mL/kg), fluoxetine (25 mg/kg), and incremental doses of 25, 50, and 100 mg of MSSE, respectively, 45 min prior to the experiment. On FST, the duration of immobility in control group, which was 161.5 ± 6.78 (in seconds, mean ± standard error of mean [SEM]), decreased to 149.33 ± 2.70 (25 mg/kg MSSE), 120.17 ± 8.35 (50 mg/kg MSSE), and 45.17 ± 4.11 (100 mg/kg MSSE) in the treated groups. On TST, the duration of immobility in control group, which was 173.83 ± 12.65 (mean ± SEM), decreased to 163.17 ± 6.91 (25 mg/kg MSSE), 139.0 ± 5.9 (50 mg/kg MSSE), and 124.0 ± 4.42 (100 mg/kg MSSE) in the treated groups. The difference in the duration of immobility was statistically significant at middle and higher doses, i.e. 50 and 100 mg/kg MSSE (P < 0.05) respectively, when compared with the control group in both the tests. A significant antidepressant-like activity was found in MSSE, which could be a potential natural compound for use in depression.

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    Reddy, A. J., Handu, S. S., Dubey, A. K., Mediratta, P. K., Shukla, R., & Ahmed, Q. M. (2016). Effect of Musa sapientum Stem Extract on Animal Models of Depression. Pharmacognosy Research, 8(4), 249-252. https://doi.org/10.4103/0974-8490.188876

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0