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Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara

1, 1★, 2, 2★ Corresponding author

  1. 1Department of Biotechnology, Kongunadu Arts and Science College
  2. 2Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India

CORRESPONDENCE

Ramaraj Thirugnanasampandan

Department of Biotechnology, Kongunadu Arts and Science College

rtsampandan@yahoo.com

Volume 8, Issue 3 · pp. 206-208 · 2016 · DOI: 10.4103/0974-8490.182920

ABSTRACT

Isodon (Lamiaceae) is a known source of bioactive terpenoids. Diterpenoids isolated from Isodon wightii (Bentham) H. Hara showed antibacterial, antiacetylcholinesterase, antioxidant, anticancer, and anticarcinogenic activities, etc., Hepatoprotective activity of ABA against lipopolysaccharide (LPS) induced liver injury in BALB/c mice was studied. Cytotoxic activity of ABA was tested against cervical cancer cells (HeLa) using MTT assay followed by propidium iodide (PI) staining to identify apoptosis. Histopathological analysis revealed that 1.5 mg/mL LPS induced liver damage was attenuated by ABA in a dose dependent manner. ABA showed cytotoxicity with IC50 value of 176.28 ± 0.02 mg/mL and PI staining of treated cells showed apoptosis. This study proves that ABA would be a promising natural compound for herbal drug preparation.

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    Ramnath, M. G., Thirugnanasampandan, R., Mathusalini, S., & Mohan, P. S. (2016). Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara. Pharmacognosy Research, 8(3), 206-208. https://doi.org/10.4103/0974-8490.182920

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0