Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Communication

Croton grewioides Baill. (Euphorbiaceae) Shows Antidiarrheal Activity in Mice

1, 2, 2, 3, 4, 1, 1, 1★★ Corresponding author

  1. 1Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
  2. 2Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57020-720, AL, Brazil
  3. 3Institute for Research on Drugs and Medicines, Federal University of Paraíba, João Pessoa 58051- 900, PB, Brazil
  4. 4Department of Molecular Biology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil

CORRESPONDENCE

Fabiana de Andrade Cavalcante

Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil

fabianacavalcante@ltf.ufpb.br

Volume 8, Issue 3 · pp. 202-205 · 2016 · DOI: 10.4103/0974-8490.181465

ABSTRACT

Based on chemotaxonomy, we decided to investigate the possible antidiarrheal activity in mice of a crude ethanolic extract obtained from aerial parts of Croton grewioides (CG-EtOH). We tested for any possible toxicity in rat erythrocytes and acute toxicity in mice. Antidiarrheal activity was assessed by determining the effect of CG-EtOH on defecation frequency, liquid stool, intestinal motility and intestinal fluid accumulation. CG-EtOH showed no in vitro cytotoxicity and was not orally lethal. In contrast, the extract given intraperitoneally (at 2000 mg/kg) was lethal, but only in females. CG-EtOH produced a significant and equipotent antidiarrheal activity, both in defecation frequency (ED50 = 106.0 ± 8.1 mg/kg) and liquid stools (ED50 = 105.0 ± 9.2 mg/kg). However, CG-EtOH (125 mg/kg) decreased intestinal motility by only 22.7% ±4.4%. Moreover, extract markedly inhibited the castor oil-induced intestinal contents (ED50 = 34.6 ± 5.4 mg/kg). We thus conclude that CG-EtOH is not orally lethal and contains active principles with antidiarrheal activity, and this effect seems to involve mostly changes in intestinal secretion.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Silva, A. D. S. D., Silva, K. D. M. E., Neto, J. C., Costa, V. C. D. O., Pessôa, H. D. L. F., Tavares, J. F., Silva, M. S. D., & Cavalcante, F. D. A. (2016). Croton grewioides Baill. (Euphorbiaceae) Shows Antidiarrheal Activity in Mice. Pharmacognosy Research, 8(3), 202-205. https://doi.org/10.4103/0974-8490.181465

    Copyright and licence

    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0