Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae)

1★, 1, 2, 1,2, 3, 2, 3★ Corresponding author

  1. 1Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA), 2Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), 3Centre de Recherche en Agriculture Biologique et Substances Naturelles (CRABISNA)
  2. 2Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA), 2Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM)
  3. 3Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), 4Laboratoire de Physiologie et de Pharmacologie, Faculté des Sciences, Université de Lomé, B.P. 1515

CORRESPONDENCE

Kokou Anani

Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA)

kokouanani@gmail.com

Volume 8, Issue 2 · pp. 142-146 · 2016 · DOI: 10.4103/0974-8490.172657

ABSTRACT

Jatropha multifida is used in Togolease folk medicine for the healing of chronic wounds. This study aims to investigate antibacterial, anti-inflammatory and antioxidant activities of the leaves ethanolic extract. The antimicrobial activity was assayed by National Committee for Clinical Laboratory Standards broth microdilution method on strains of Staphylococcus aureus and Pseudomoas aeruginosa isolated from wounds, whereas the anti-inflammatory activity was performed by carrageenan and histamine induced paw edema method in rat modele. The 2, 2-diphenyl- 1picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) were used for the antioxidant activity. The antibacterial assay showed an in vitro growth inhibition of P. aeruginosa and S. aureus in dose-dependent manner, with minimum inhibitory concentration values ranging from 2.5 to 3.12 mg/mL for S. aureus and from 6.25 to 12.5 mg/mL for P. aeruginosa. The maximum paw anti-inflammatory effect occurred after 3 and 5 h administration of histamine and carrageenan, respectively. The DPPH radical scavenging and the FRAP assays yielded weak antioxidant activity. J. multifida possesses antibacterial and anti-inflammatory activities that could justify the use of the plant for the treatment of wounds in the folk medicine.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Anani, K., Adjrah, Y., Améyapoh, Y., Karou, S. D., Agbonon, A., Souza, C. D., & Gbeassor, M. (2016). Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae). Pharmacognosy Research, 8(2), 142-146. https://doi.org/10.4103/0974-8490.172657

    Copyright and licence

    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0