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A study of Nigella sativa induced growth inhibition of MCF and HepG2 cell lines: An anti-neoplastic study along with its mechanism of action

1, 2, 3★★ Corresponding author

  1. 1Departments of Pharmaceutcal Analysis
  2. 2Department of Chemistry, JNTUA, Ananthapuramu, Andhra Pradesh, India
  3. 3Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research

CORRESPONDENCE

Mohammed Jaffar Sadiq

Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research

jaffar909@yahoo.com

Volume 7, Issue 2 · pp. 193-197 · 2015 · DOI: 10.4103/0974-8490.150541

ABSTRACT

To evaluate the anticancer potential of seeds of Nigella sativa using MCF and HepG2 cell lines along with its mechanism of action. (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and acridine orange/ethidium bromide nuclear staining technique were selected to evaluate anticancer potential and mechanism of action of test extract. Aqueous extract of N.sativa at a test dose of 180 mg and 300 mg was identified to be the best as anticancer agent against MCF and HepG2 cell lines among different solvent test extract where doxorubicin and cisplatin were employed as standard references. Further study including separation and characterization of active principles in the aqueous extract shall prove beneficial.

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    Reddy, Y. P., Chandrasekhar, K. B., & Sadiq, M. J. (2015). A study of Nigella sativa induced growth inhibition of MCF and HepG2 cell lines: An anti-neoplastic study along with its mechanism of action. Pharmacognosy Research, 7(2), 193-197. https://doi.org/10.4103/0974-8490.150541

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    © 2015 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0