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Development of phytovesicles containing triterpenoids from Samadera indica

1★, 1, 1, 2★ Corresponding author

  1. 1Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwavidyapeetham University, AIMS, Kochi
  2. 2Department of Pharmaceutics, Caritas College of Pharmacy, Kottayam, Kerala, India

CORRESPONDENCE

Vidya Viswanad

Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwavidyapeetham University, AIMS, Kochi

vidyaviswanad@aims.amrita.edu

Volume 7, Issue 2 · pp. 176-183 · 2015 · DOI: 10.4103/0974-8490.151461

ABSTRACT

Samadera indica belonging to Simaroubaceae family is being used traditionally for many diseases including arthritis, edema, itching, skin diseases, constipation, and general debility. The effectiveness of any drug delivery system depends upon its ability to deliver the active components at therapeutic level. In this study, a novel phyto vesicular formulation for the enhanced topical delivery of methanol extract of S. indica in order to treat skin infections was developed. The methanol extract fraction of leaves of S. indica which showed more antifungal activity was purified to separate an antifungal compound. Phytovesicles were formulated using the more antifungal fraction in order to treat topical and deep seated fungal infections. Pytovesicles were prepared using 1:2 molar ratio of antifungal triterpenoid from S. indica (AFTSI)-phosphatidylcholine by film hydration method. Chloroform 100% fraction of methanol extract of S. indica showed more activity against the fungus Candida albicans. Further purification gave a fraction with minimum inhibitory concentration value of 15.6 μg/ml against C. albicans and showed positive test for triterpenoids. The fraction was named as AFTSI. A compound (20 mg) was isolated from this fraction at an RF value. The phytovesicle gel formulated using AFTSI showed enhanced skin permeability and antifungal activity. The study demonstrated that the phytovesicular gel developed using methanol extract of S. indica would be beneficial for treating deep seated fungal infections.

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    Viswanad, V., Zachariah, S. M., Sathi, A., & Aleykutty, N. A. (2015). Development of phytovesicles containing triterpenoids from Samadera indica. Pharmacognosy Research, 7(2), 176-183. https://doi.org/10.4103/0974-8490.151461

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    © 2015 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0