Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

Novel strategies for optimized delivery of select components of Allium sativum

1, 1, 1★★ Corresponding author

  1. 1Department of Pharmacognosy, Bombay College of Pharmacy, Kalina, Santacruz, Mumbai, Maharashtra, India

CORRESPONDENCE

Alka Mukne

Department of Pharmacognosy, Bombay College of Pharmacy, Kalina, Santacruz, Mumbai, Maharashtra, India

a_mukne@yahoo.com

Volume 6, Issue 4 · pp. 334-340 · 2014 · DOI: 10.4103/0974-8490.138288

ABSTRACT

Garlic (Allium sativum) has been known to exhibit a wide range of pharmacological activities which are attributed mainly to the organosulfur compounds present in it. Allicin and garlic oil, components obtained from garlic, have been explored and found to be biologically active on various fronts. Allicin is known to have major stability issues due to rapid degradation even at low temperatures, whereas garlic oil, being lipophilic, shows poor bioavailability after oral administration. To develop novel strategies for optimum delivery of allicin and garlic oil so as to achieve effective availability in the physiological system. Garlic cloves were lyophilized to obtain allicin-releasing garlic powder (ARGP). This powder was analyzed spectrophotometrically and was used to formulate buccal tablets. Garlic oil was obtained by hydrodistillation of garlic cloves and analyzed by gas chromatography. Self-nanoemulsifying systems (SNS) containing garlic oil were prepared using suitable surfactants and cosurfactants. The SNS were adsorbed on Aerosil 200 and filled in hard gelatin capsules. Both the formulations were suitably evaluated. Buccal tablets containing ARGP showed satisfactory physical parameters as well as in vitro drug release, mucoadhesive strength, moisture uptake capacity and drug content. Evaluation of capsules containing SNS of garlic oil also gave satisfactory results. The adsorbed SNS when dispersed in water formed nanoemulsions. Buccal tablets as well as capsules containing garlic oil SNS provide promising strategies to overcome the difficulties associated with formulation of allicin and garlic oil.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Phadatare, A. G., Viswanathan, V., & Mukne, A. (2014). Novel strategies for optimized delivery of select components of Allium sativum. Pharmacognosy Research, 6(4), 334-340. https://doi.org/10.4103/0974-8490.138288

    Copyright and licence

    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0