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Anticancer Active Homoisoflavone from the Underground Bulbs of Ledebouria hyderabadensis

1, 2, 1, 1, 1★, 1, 2, 3★ Corresponding author

  1. 1CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Natura Products Chemistry, Boduppal
  2. 2Toxicology Unit, Biology Division, CSIR-IICT, Tarnaka
  3. 3Department of Botany, Nizam College, Osmania University, Hyderabad, Andhra Pradesh, India

CORRESPONDENCE

Jonnala Kotesh Kumar

CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Natura Products Chemistry, Boduppal

koteshkumarj@yahoo.com

Volume 6, Issue 4 · pp. 303-305 · 2014 · DOI: 10.4103/0974-8490.138272

ABSTRACT

Ledebouria is a genus of deciduous or weakly evergreen bulbs in the Hyacinthaceae family. This is recognized as the first collection made of the new taxon Ledebouria hyderabadensis, exist in the Hyderabad city of Andhra Pradesh, India. The goal of this work was to investigate the phytochemical constituents present in the new specifies and also to evaluate the cytotoxic properties of the extracts and pure compounds against human cancer cell lines. The anticancer activity was evaluated in in vitro mode by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test. Phytochemical investigation of underground bulbs of indigenous, rare, and recently identified herb L. hyderabadensis yielded a bioactive homoisoflavanone, Scillascillin 1. The structure of the compound was established on the basis of various nuclear magnetic resonance and mass spectral data. The compound Scillascillin was isolated for the first time from L. hyderabadensis. In vitro anticancer activity, performed using MTT assay, showed compound 1 as significantly active against human cancer cell lines MCF-7 (breast cancer) and DU-145 (prostate cancer) with inhibitory concentration (IC) 50 values 9.59 and 11.32 mg/ml respectively when compared with herb methanol extract (IC50 values 36.21 and 44.86 mg/ml respectively).

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    Chinthala, Y., Chinde, S., kumar, A. N., Srinivas, K. V. N. S., Kumar, J. K., Sastry, K. P., Grover, P., & Ramana, M. V. (2014). Anticancer Active Homoisoflavone from the Underground Bulbs of Ledebouria hyderabadensis. Pharmacognosy Research, 6(4), 303-305. https://doi.org/10.4103/0974-8490.138272

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0