Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome

1, 2, 3, 1★★ Corresponding author

  1. 1Faculty of Pharmacy, Kinki University 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502
  2. 2Japan Tablet Corporation 149-1 Mekawa, Makishima, Uji, Kyoto 611-0041
  3. 3Inabata Koryo Co., Ltd 3-5-20 Tagawa, Yodogawa-ku, Osaka 532-0027, Japan

CORRESPONDENCE

Hideaki Matsuda

Faculty of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502

matsuda@phar.kindai.ac.jp

Volume 5, Issue 4 · pp. 309-314 · 2013 · DOI: 10.4103/0974-8490.118827

ABSTRACT

Kaempferia parviflora rhizome is used as a folk medicine in Thailand for the treatment of various symptoms. In the present study, the inhibitory activities of extract from K. parviflora rhizome against 5a-reductase (5aR) were subjected. Furthermore, the effects of the extract from K. parviflorar hizome in benign prostate hyperplasia (BPH) were studied using the model mice. Preparations of extracts from the rhizomes of K. parviflora, Curcuma zedoaria and Zingiber officinale, and methoxyflavones isolated from K. parviflora was used for 5aR inhibition assay. The effects of K. parviflora extract on growth suppression for the prostates and seminal vesicles were performed based on the Hershberger’s method. The K. parviflora extract was administered to castrated mice for 14 days. K. parviflora extract showed more potent inhibitory activity on 5aR than C. zedoaria and Z. officinale extracts. The active principles were identified as 3,5,7,3’,4’-pentamethoxyflavone and 5,7,3’,4’-tetramethoxyflavone by activity guided fractionation. Furthermore, K. parviflora extract suppressed the weights of prostates and seminal vesicles in BPH model rats by daily administration for 14 days. These results indicate that K. parviflora extract can be a promising agent for the treatment of BPH.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Murata, K., Hayashi, H., Matsumura, S., & Matsuda, H. (2013). Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome. Pharmacognosy Research, 5(4), 309-314. https://doi.org/10.4103/0974-8490.118827

    Copyright and licence

    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0