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Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation

1, 1, 1★★ Corresponding author

  1. 1Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India

CORRESPONDENCE

H. N. Aswatha Ram

Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India

aswatharam@gmail.com

Volume 5, Issue 4 · pp. 306-308 · 2013 · DOI: 10.4103/0974-8490.118824

ABSTRACT

Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases. The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC. The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out. Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001). From the above results, it has been justified that SPC can be used to treat allergic disorders.

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    Makhija, I. K., Shreedhara, C. S., & Ram, H. N. A. (2013). Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation. Pharmacognosy Research, 5(4), 306-308. https://doi.org/10.4103/0974-8490.118824

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    © 2013 Author(s)

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