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Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum

1★, 2, 1, 1, 1, 3★ Corresponding author

  1. 1Department of Chemistry of Natural Compounds, National Research Centre, Dokki
  2. 2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University
  3. 3Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt

CORRESPONDENCE

Mahmoud I. Nassar

Department of Chemistry of Natural Compounds, National Research Centre, Dokki

mnassar_eg@yahoo.com

Volume 5, Issue 1 · pp. 17-21 · 2013 · DOI: 10.4103/0974-8490.105643

ABSTRACT

Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation. Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves. Identification of a new flavone glycoside, acacetin 8-C-b–D- glucopyranosy l-(1®2)–a-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD50) revealed that the different extracts were safe.

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    Nassar, M. I., Aboutabl, E. A., Eskander, D. M., Grace, M. H., EL-Khrisy, E. A., & Sleem, A. A. (2013). Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum. Pharmacognosy Research, 5(1), 17-21. https://doi.org/10.4103/0974-8490.105643

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0