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Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies

1, 2★, 1, 1, 3, 4, 4, 5, 6★ Corresponding author

  1. 1Department of Pharmacology, University of Ghana Medical School
  2. 2Department of Medical Laboratory Sciences, School of Allied Health Sciences
  3. 3Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana
  4. 4Animal Experimentation Unit, NMIMR
  5. 5Center for Scientific Research into Plant Medicine, Mampong, Akuapim, Ghana
  6. 6Clinical Pathology, NMIMR

CORRESPONDENCE

George A. Asare

Department of Medical Laboratory Sciences, School of Allied Health Sciences

gasare@chs.edu.gh

Volume 5, Issue 1 · pp. 10-16 · 2013 · DOI: 10.4103/0974-8490.105640

ABSTRACT

Croton membranaceus (CM) is used for benign prostate hyperplasia treatment. Sub-chronic toxicity studies are non-existent and provided the basis for this study. 90 days oral administration of a low dose (LD) (30 mg/kg b. wt.), medium dose (MD) (150 mg/kg b. wt.), and high dose (HD) (300 mg/kg b. wt.) CM aqueous root extract to 3 groups (n=6 each) of male Sprague-Dawley rats, alongside a control group, was undertaken. Urinalysis, hepato-renal function tests, lipid profile, cardiac enzymes, and routine hematology tests were performed. Triglyceride levels (C=1.05±0.19, LD=0.64±0.08, MD=0.55±0.04, HD=0.50±0.02 mmol/L) were significantly reduced (P<0.05). Very low density lipoprotein (C=0.48±0.09, LD=0.29±0.04, MD=0.25±0.02, HD=0.23±0.01 mmol/L) decreased significantly (P<0.05). Cardiac enzymes-creatinine kinase (C=568±172, LD=315±79, MD=441±209, HD=286±81 IU/L) decreased markedly (P<0.05) alongside lactate dehydrogenase (C=2675±875, LD=1667±1229, MD=1186±442, HD=855±239 IU/L) (P<0.05). C. membranaceus aqueous root extract is non-toxic but demonstrates anti-atherogenic and anti-ischemic potentials.

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    Afriyie, D. K., Asare, G. A., Bugyei, K., Asiedu-Gyekye, I., Gyan, B. A., Adjei, S., Addo, P., Sittie, A., & Nyarko, A. K. (2013). Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies. Pharmacognosy Research, 5(1), 10-16. https://doi.org/10.4103/0974-8490.105640

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0