Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata

1, 2, 3, 1,2, 3, 4

  1. 1School of Chinese Medicine, Bozhou University, Bozhou, CHINA., 2Key Laboratory of Chinese Medicine Materials Research of Anhui Higher Education Institutes, Bozhou University, Bozhou, CHINA.
  2. 2School of Chinese Medicine, Bozhou University, Bozhou, CHINA.
  3. 3School of Pharmacy, Jiangsu University, Zhenjiang, CHINA.
  4. 4Department of Neurology, The Affiliated Fourth People's Hospital of Jiangsu University, Zhenjiang, CHINA.

CORRESPONDENCE

Prof. Jian Tang

[1]School of Chinese Medicine, Bozhou University, Bozhou-236800, CHINA. [2]Key Laboratory of Chinese Medicine Materials Research of Anhui Higher Education Institutes, Bozhou University, Bozhou-236800, CHINA.

jt.u@hotmail.com

Received: 28-02-2025; Accepted: 03-06-2025.

Volume 17, Issue 3 · pp. 1020-1028 · 2025 · DOI: 10.5530/pres.20252269

ABSTRACT

The classic anxiolytics have adverse effects in the treating anxiety disorders. To identify the anxiolytic polysaccharide from Sargentodoxa cuneata. The water-soluble Polysaccharide Fraction (PSC) was purified from S. cuneata, as well as its subfractions PSCA-1 and PSCB-1. The antioxidant effect of PSC against rotenone induced PC12 cell excitotoxicity, stimulating telomerase effect in HEK293T cell and anxiolytic effect on zebrafish were evaluated. The pretreatment of PC12 with PSC obviously increased cell survival and SOD level. PSC also down-regulated the LDH release, ROS level and cell apoptosis rate. PSC promoted the 293T cell proliferation, associated with the mechanism of stimulating telomerase. Additionally, PSC alleviated the anxiety level in zebrafish induced by mCPP. These findings suggested that the PSC could possess the anxiolytic potential via antioxidant and telomerase activation.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Tang, J., Zhou, P., Sun, H., Xu, X., Wen, C., & Xia, H. (2025). Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata. Pharmacognosy Research, 17(3), 1020-1028. https://doi.org/10.5530/pres.20252269

    Copyright and licence

    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0