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Xylopia aethiopica Fruit Macerate Inhibits Carrageenan-induced Pleurisy in Rats

1, 1, 2, 1, 1, 3, 4, 3

  1. 1Unité de Recherche en Immunologie et Immunomodulation (UR2IM)/Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires/Ecole Supérieure des Techniques Biologiques et alimentaires (ESTBA), Université de Lomé, TOGO.
  2. 2Département de Pharmacie, Faculté des Sciences de la Santé (FSS), Université de Lomé, TOGO.
  3. 3Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, GERMANY., 4German-West African Centre for Global Health and Pandemic Prevention (G-WAC), partner site Bonn, Bonn, GERMANY.
  4. 4Laboratoire de Biologie et Ecologie Végétale, Faculté des Sciences (FDS), Université de Lomé, TOGO.

CORRESPONDENCE

Dr. Gnatoulma Katawa

Ecole Supérieure des Techniques Biologiques et alimentaires/Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires /Unité de Recherche en Immunologie et Immunomodulation (UR2IM), Université de Lomé, Togo, BP 1515, Lomé, TOGO.

mahkatawa@yahoo.fr

Received: 24-02-2025; Accepted: 28-05-2025.

Volume 17, Issue 3 · pp. 1005-1019 · 2025 · DOI: 10.5530/pres.20252238

ABSTRACT

Pleurisy is an inflammatory condition of the pleura that can lead to severe morbidity and mortality. Controlling excessive pleural inflammation is crucial. Xylopia aethiopica, known for its anti-inflammatory properties, may be a potential treatment. This study evaluates its immunological mechanisms and toxicological impact. Wistar rats were pre-treated with either chloroquine or X. aethiopica fruit macerate before carrageenan-induced pleurisy. Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-α) levels were measured in blood and pleural exudate via sandwich ELISA. Leukocyte counts were also assessed. Acute and subacute toxicity profiles of the macerate were evaluated in rats. Carrageenan injection induced an inflammatory condition, resulting in increased local and systemic TNF-α and IL-6 levels, with increased leukocyte influx in the pleural cavity. X. aethiopica macerate significantly reduced systemic (p=0.0026) and local (p=0.0004) TNF-α levels, comparable to chloroquine. No acute toxic effects were observed within 48 hours or 14 days. A 28-day oral administration did not induce behavioral changes, and biochemical analyses suggested safety at studied doses. However, histological analyses revealed vascular congestion and inflammation in the liver and kidneys. X. aethiopica macerate exhibits significant anti-inflammatory effects, supporting its potential as a pleurisy treatment. Further research is needed to confirm its clinical applications.

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    Katawa, G., Bara, F. D., Daria, F., Tchadie, P. E., Gnodja, T., Arndts, K., Batawila, K., & Ritter, M. (2025). Xylopia aethiopica Fruit Macerate Inhibits Carrageenan-induced Pleurisy in Rats. Pharmacognosy Research, 17(3), 1005-1019. https://doi.org/10.5530/pres.20252238

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    © 2025 Author(s)

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