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Green Synthesis of Gold Nanoparticles Using Sphaeranthus amaranthoides: Drug Loading and Anticancer Properties in Nanomedicine

1, 1★, 1, 1, 1★ Corresponding author

  1. 1Department of Nano Science and Technology, Sathyabama Institute of Science and Technology (Deemed to be University), Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

Swarnalatha Yanamadala

Department of Nano Science and Technology, Sathyabama Institute of Science and Technology (Deemed to be University), Chennai, Tamil Nadu, INDIA.

lokiswarna@gmail.com

Received: 20-09-2024; Accepted: 03-12-2024.

Volume 17, Issue 1 · pp. 108-114 · 2025 · DOI: 10.5530/pres.20251946

ABSTRACT

This study introduces a sustainable method for synthesizing anisotropic Sphaeranthus amaranthoides leaf extract reduced gold nanoparticles (S-GNPs) by utilizing the phenolic compounds present in Sphaeranthus amaranthoides leaf extract. Unlike conventional chemical methods, this eco-friendly approach leverages natural sunlight as a catalyst and hyaluronic acid for stabilization, providing a green, scalable solution. The research aims to develop a biocompatible, stable nanoparticle system for targeted cancer drug delivery. The nanoparticles were synthesized and characterized using Surface Plasmon Resonance (SPR) and High-Resolution Transmission Electron Microscopy (HRTEM) to confirm size, morphology, and zeta potential. Stability was tested in saline solutions at physiological pH. In vivo toxicity studies were conducted using zebra fish larvae, demonstrating high biocompatibility at concentrations below 100 µg/mL. Dexamethasone-loaded S-GNPs exhibited significant cytotoxicity against THP-1 Acute Monocytic Leukemia cells, underscoring the potential of this eco-friendly synthesis method for cancer therapy applications. These findings highlight the viability of S-GNPs as effective, biocompatible vehicles for targeted drug delivery, presenting a sustainable alternative to conventional nanoparticle systems.

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    Khan, I. S., Yanamadala, S., Chinnaiyan, S., Chiterasu, N., & Kannan, S. (2025). Green Synthesis of Gold Nanoparticles Using Sphaeranthus amaranthoides: Drug Loading and Anticancer Properties in Nanomedicine. Pharmacognosy Research, 17(1), 108-114. https://doi.org/10.5530/pres.20251946

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    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0