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Ethanolic Extract of aerial parts of Achyranthes aspera Attenuates Hepatotoxicity and Nephrotoxicity Induced by Cisplatin in Rat

1★, 1, 1★ Corresponding author

  1. 1Department of Pharmacology, Geetanjali Institute of Pharmacy, Geetanjali University, Udaipur, Rajasthan, INDIA.

CORRESPONDENCE

Arijit Chaudhuri

Department of Pharmacology, Geetanjali Institute of Pharmacy, Geetanjali University, Udaipur, Rajasthan, INDIA.

armanchaudhuri92@gmail.com

Received: 07-08-2024; Accepted: 27-11-2024.

Volume 17, Issue 1 · pp. 60-69 · 2025 · DOI: 10.5530/pres.20251905

ABSTRACT

The chemotherapeutic agents used to treat cancer are known to possess potent adverse effects like nephrotoxicity and hepatotoxicity among others. The aim of this current study happened to be the isolation of phytoconstituent from Achyranthes aspera and assess the protective effect of the compound against cisplatin-induced hepato- and nephrotoxicity in rats. Toluene: Ethyl Acetate (9:1) was used as the solvent system to isolate the phenolic compound from ethanolic extract of the leaves and stem of A. aspera. The isolated compounds were studied using mass spectroscopy, 1H NMR, FT-IR and UV. The effect of the isolated phenolic was assessed by study of various factors like body weight, organ weight, serum biomarkers and histopathological studies. The treatment of cisplatin led to a significant increase the weight of the organs, hepatic and kidney biomarkers in serum suggesting toxicity whereas the the isolated component reversed the elevated levels (p<0.05 compared to positive control). It could be concluded from the results that pretreatment with isolated component (coumarin) was able to attenuate the hepato-and nephron-toxicity induced by anticancer drug cisplatin.

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    Chaudhuri, A., Kataria, U., & Dubey, A. (2025). Ethanolic Extract of aerial parts of Achyranthes aspera Attenuates Hepatotoxicity and Nephrotoxicity Induced by Cisplatin in Rat. Pharmacognosy Research, 17(1), 60-69. https://doi.org/10.5530/pres.20251905

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    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0