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Anti-inflammatory Potential of Euphorbia helioscopia Extracts against RAW264.7 Macrophages

1, 2, 3, 2, 3, 2, 1

  1. 1School of Life Sciences, Jaipur National University, Jaipur, Rajasthan, INDIA.
  2. 2Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Canal Road Jammu, Jammu and Kashmir, INDIA., 4Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, INDIA.
  3. 3PK-PD Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, INDIA., 4Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, INDIA.

CORRESPONDENCE

Iram Jan

School of Life Sciences, Jaipur National University, Jaipur, Rajasthan, INDIA.

iramjan911@gmail.com

Volume 14, Issue 3 · pp. 338-341 · 2022 · DOI: 10.5530/pres.14.3.50

ABSTRACT

Background: Euphorbia helioscopia, commonly known as sun spurge, is one of the largest species of an annual herb in the family Euphorbiaceae, which is extensively distributed worldwide. In folk medicine, it is used to treat various ailments such as malaria, osteomyelitis, and gastrointestinal ailments. The anti-inflammatory potential of Euphorbia helioscopia extracts on LPS-stimulated RAW264.7 macrophages was investigated in this work.Results: The ethanol extract was found to markedly inhibit the pro-inflammatory cytokines (IL-6 and TNFα) production compared to the aqueous extract treated cells. Moreover, extracts downregulated the nitric oxide levels. Finally, in this study, we have shown that Euphorbia helioscopia exerts a potent pharmacological effect on reducing the inflammatory response in macrophages.Conclusion: The results of the experiment revealed that the Euphorbia helioscopia extracts used in this study have anti-inflammatory characteristics, with the ethanolic extract having the most. The ethanolic extract had the strongest anti-inflammatory impact in terms of greatest reduction of proinflammatory indicators including IL-6, TNF-, and NO.

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    Jan, I., Andrabi, N. I., Arfath, Y., Akram, T., Kotra, T., Ahmed, Z., & Kumar, M. (2022). Anti-inflammatory Potential of Euphorbia helioscopia Extracts against RAW264.7 Macrophages. Pharmacognosy Research, 14(3), 338-341. https://doi.org/10.5530/pres.14.3.50

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    © 2022 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0