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In silico Investigation on Phytoconstituents in Pamburus missionis S. for Antioxidant Activity

1, 1, 1, 1, 1, 2

  1. 1Department of Pharmacognosy, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.
  2. 2Department of Pharmacognosy, Ranchi College of Pharmacy, Ranchi, Jharkhand, INDIA.

CORRESPONDENCE

Raveesha Peeriga

Department of Pharmacognosy, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.

drprsha@gmail.com

Received: 30-03-2022; Accepted: 06-06-2022.

Volume 14, Issue 3 · pp. 246-250 · 2022 · DOI: 10.5530/pres.14.3.35

ABSTRACT

Background: Pamburus missionis is geographically originated from southern India and it has been used for ailments.Objectives: This current research was performed to analyze in silico evaluation of phytoconstituents present in Pamburus missionis for antioxidant activity.Materials and Methods: In silico activity of the isolated constituents for antioxidant activity was carried out by Autodock 4.0 and absorption, distribution, metabolism, excretion/toxicity assessed by online tools.Results: The results revealed that the phytocompounds, benzoic acid 2,3-dimethyl showed the good docking score of -5.8 kcal/mol, which was a mere docking score of standard curcumin, i.e., -6.6 kcal/mol hence proving that a good binding compatibility among the ligand and the receptor site NADPH oxidase. The Absorption, distribution, metabolism, excretion/toxicity evaluation of phytoconstituents assures that they had obeyed Lipinski’s guideline of five suggesting their safety consumption.Conclusion: To conclude, Pamburus missionis can be a good resource of antioxidant activity and simulation studies is needed to ensure the antioxidant activity of benzoic acid 2,3-dimethyl.

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    Peeriga, R., Adarapu, K. P., Kurama, A., Mohammed, N., Atmakuri, L. R., & Kumar, D. (2022). In silico Investigation on Phytoconstituents in Pamburus missionis S. for Antioxidant Activity. Pharmacognosy Research, 14(3), 246-250. https://doi.org/10.5530/pres.14.3.35

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    © 2022 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0