Article · Volume 9, Issue 5s · pp. s23-s26
Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract
Mahesh Kumar1, Jeyabalan Govindrajan1, Narendra Kumar Nyola2
- 1Faculty of Pharmacy, Rajasthan University of Health Sciences, Jaipur., 2Department of Pharmacognosy, Alwar College of Pharmacy, Alwar, Rajasthan, India.
- 2Department of Pharmacognosy, Alwar College of Pharmacy, Alwar, Rajasthan, India.
Abstract
Background: Indian traditional system of medicine uses Pithecellobium dulce for the treatment of diabetes mellitus.Objectives: This study aims to develop an extract rich in saponins derived from seeds of the plant and to evaluate its antihyperglycemic potential in vitro and in vivo.Materials and Methods: Defatted seeds were extracted with methanol and processed to afford saponin-enriched fraction (PDSEF). The fraction was evaluated for α-glucosidase and α-amylase inhibition.Results: PDSEF showed superior enzyme inhibition compared to acarbose and was safe up to 2000 mg/kg.Conclusion: PDSEF displayed excellent antihyperglycemic activity in vitro and in vivo.
Keywords: Antihyperglycemic; Pithecellobium dulce; Saponins; α-amylase; α-glucosidase
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