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Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats

1, 2, 3, 3, 2, 2

  1. 1Department of Animal Biology Organisms, Faculty of Science, University of Douala 24157, Douala; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1 812, Yaounde, Cameroon, 3INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.
  2. 2Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1 812, Yaounde, CAMEROON.
  3. 3INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III F31432, Toulouse, FRANCE.

CORRESPONDENCE

Marie Claire Tchamadeu

Department of Animal Biology Organisms, Faculty of Science, University of Douala

marieclaire_tchamadeu@yahoo.fr

Volume 9, Issue 1 · pp. 80-86 · 2017 · DOI: 10.4103/0974-8490.199767

ABSTRACT

Aim of the Study: The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxii Taub in normal and diabetic rats.Materials and Methods: Streptozotocin (STZ)‑induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH2Cl2/CH3OH plant extracts of P. soyauxii at various doses (38–300 mg/kg) in a single administration. In addition, STZ‑induced diabetic rats received prolonged daily administration for 14 days. Glibenclamide (GB) (10 mg/kg) was used as reference treatment. In acute test, fasting blood glucose was followed for 5 h. In subacute test, body weight, food and water intakes, and blood glucose were followed weekly and serum biochemical parameters evaluated after 14 days treatment.Results: Acute administration of aqueous and CH2Cl2/ CH3OH stem bark extracts moderately decreased fasting blood glucose compared to GB, significantly in normal rats (P < 0.05 to P < 0.01) but, as GB, not significantly in diabetic rats. Prolonged treatments in diabetic rats with aqueous and CH2Cl2/CH3OH extracts reduced blood glucose to an extent, respectively, superior or similar to GB. Moreover, P. soyauxii also significantly (P < 0.01) reduced weight loss, and diabetes increased serum triglycerides, total cholesterol, and transaminases (alanine aminotransferase/ aspartate aminotransferase) elevations.Conclusion: P. soyauxii Taub stem bark extracts have possible value for antidiabetic oral medication.

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    Tchamadeu, M. C., Dzeufiet, P. D. D., Blaes, N., Girolami, J., Kamtchouing, P., & Dimo, T. (2017). Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats. Pharmacognosy Research, 9(1), 80-86. https://doi.org/10.4103/0974-8490.199767

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    © 2017 Author(s)

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