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Ulcer Protective Activity of Jatropha gossypiifolia Linn. in Wistar Rats

1, 1, 2★, 3, 4★ Corresponding author

  1. 1Department of Pharmacology, CL Baid Metha College of Pharmacy
  2. 2Department of Pharmacology, Captain Srinivasa Murti Drug Research Institute for Ayurveda and Siddha Drug Development, CCRAS, Ministry of AYUSH, Government of India, Arumbakkam
  3. 3CL Baid Metha Foundation for Pharmaceutical Education and Research, Thoraipakkam
  4. 4Department of Pharmacy Practice, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai, Tamil Nadu, India

CORRESPONDENCE

Raju Ilavarasan

Department of Pharmacology, Captain Srinivasa Murti Drug Research Institute for Ayurveda and Siddha Drug Development, CCRAS, Ministry of AYUSH, Government of India, Arumbakkam

arilavarasan@yahoo.co.in

Volume 8, Issue 5s · pp. S61-S66 · 2016 · DOI: 10.4103/0974-8490.178640

ABSTRACT

Several synthetic drugs are useful in the treatment of peptic ulcer, but almost of these drugs are used in prolonging time, it may cause several adverse reactions. However, the herbal medicines are more potent to the treatment and minimize the side effects. To evaluate the methanol extract of Jatropha gossypiifolia Linn. (MEJG) for gastro protective activity against Wistar rats. Anti-ulcer potency of MEJG (100 and 200 mg/kg, b.w.) was assessed using aspirin (200 mg/kg, p.o.) plus pylorus ligation ulcer model and the parameters studied were ulcer index (UI), gastric juice volume, pH, total acidity, and total acid output. Same extract was studied by ethanol-induced (80%, 5 mL/kg, intragastrically) ulcer model, and the UI and biochemical parameters were studied. The oral administration of MEJG (100 and 200 mg/kg) significantly (P < 0.001) attenuated the ulcer score and anti-secretary parameters (such as the volume of gastric content, free acidity, total acidity, and total acid output) in the aspirin plus pylorus ligation rats. The extract also significantly attenuated (P < 0.001) ulcer score in ethanol-induced ulcer model and lipid peroxidation level and significantly increased the level of glutathione peroxides, catalase, and superoxide dismutase activity. The MEJG may possess active constituents such as alkaloids, glycosides, flavonoids, and terpenes, which may play a major role in gastroprotective effect in Wistar rats. The present study provides scientific support for the anti-ulcer activities of extracts of JG and also claimed that antioxidant potential of the extracts. However, substantiates the traditional claims for the usage of this drug in the treatment of gastric ulcer.

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    Vijayakumar, A. R., Daniel, E. P., Ilavarasan, R., Venkataraman, S., & Vijayakumar, S. (2016). Ulcer Protective Activity of Jatropha gossypiifolia Linn. in Wistar Rats. Pharmacognosy Research, 8(5s), S61-S66. https://doi.org/10.4103/0974-8490.178640

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0