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Effects of Five Bangladeshi Plant Extracts on In vitro Thrombolysis and Cytotoxicity

1, 1, 1, 1, 1, 1, 2, 3★★ Corresponding author

  1. 1Department of Pharmacy, BGC Trust University Bangladesh, Chittagong-4000
  2. 2Department of Pharmacy, Southeast University, Banani, Dhaka-1213, Bangladesh, India
  3. 3Pharmacy, University of Chittagong, Chittagong-4331

CORRESPONDENCE

Mir Muhammad Nasir Uddin

Pharmacy, University of Chittagong, Chittagong-4331

nasirmir@cu.ac.bd

Volume 8, Issue 3 · pp. 176-180 · 2016 · DOI: 10.4103/0974-8490.181403

ABSTRACT

Piper Betle, Pterospermum acerifolium, Saraca indica, Argyreia speciosa, and Rhaphidophora glauca are medicinal plants commonly used as traditional medicine for the treatment of various diseases. To examine, whether organic extracts of these plants possess thrombolytic properties with minimal or no toxicity is our main aim of the study. In vitro thrombolytic model was used to check the clot lysis effects using streptokinase (SK) as a positive control and water as a negative control. Cytotoxicity was screened by brine shrimp lethality bioassay using vincristine sulfate (VS) as positive control. Among herbal drugs, different organic extracts of P. betle, P. acerifolium, S. indica, A. speciosa, and R. glauca showed significant (P < 0.05 and P < 0.0001) clot lysis activity viz., 31.58% ±0.76%, 40.50% ±0.94%, 49.70% ±1.69%, 35.81% ±0.86%, and 43.80% ±0.91%, respectively, compared to reference drug SK (79.32% ±1.629%). In brine shrimp cytotoxic assay, mortality achieved by the extracts showed lethal concentration 50 (LC50) values 274.64 ± 3.46, 215.60 ± 4.59, 478.40 ± 6.98, 233.37 ± 2.56, and 209.32 ± 1.98 mg/ml, respectively, with reference to VS (LC50, 0.05 ± 0.34). In this study, S. indica, R. glauca, and P. acerifolium possessed effective thrombolytic activity. Further studies can be undertaken to identify certain structure of the ingredients in the extracts and to elucidate the precise mechanism of action.

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    Dash, R., Emran, T. B., Paul, A., Siddique, M. K. U., Khan, M. A., Rahman, M. G., Sarwar, M. S., & Uddin, M. M. N. (2016). Effects of Five Bangladeshi Plant Extracts on In vitro Thrombolysis and Cytotoxicity. Pharmacognosy Research, 8(3), 176-180. https://doi.org/10.4103/0974-8490.181403

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0