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Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens

1, 2, 3, 4, 4, 4★★ Corresponding author

  1. 1Departments of Marine Science and Technology
  2. 2Marine Biology
  3. 3Chemistry, Science and Research Branch, Islamic Azad University
  4. 4Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran

CORRESPONDENCE

Ahmad Reza Gohari

Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran

goharii_a@tums.ac.ir

Volume 7, Issue 4 · pp. 314-321 · 2015 · DOI: 10.4103/0974-8490.167893

ABSTRACT

Sargassum species (phaeophyceae) are economically important brown algae in southern parts of Iran. Sargassum is mainly harvested as a row material in alginate production industries and is a source of plant foods or plant bio-stimulants even a component of animal foods. In this study, Sargassum glaucescens, collected from the seashore of Chabahar, was employed for phytochemical and biological evaluations. For that purpose, the dried algae was extracted by methanol and subjected to different chromatographic separation methods. Six sterols, fucosterol (1), 24(S)-hydroxy-24-vinylcholesterol (2), 24(R)-hydroxy-24-vinylcholesterol (3), stigmasterol (4), b-sitosterol (5) and cholesterol (6) were identified by spectroscopic methods including 1H-NMR, 13C-NMR and mass spectroscopy. In vitro alpha-amylase inhibitory test was performed on the methanolic extract and the results revealed a potent inhibition (IC50 = 8.9 ± 2.4 mg/mL) of the enzyme compared to acarbose as a positive control. Various biological activities and distribution of sterols in Sargassum genus have been critically reviewed here. The results concluded that these algae are a good candidate for further anti-diabetic investigations in animals and human.

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    Payghami, N., Jamili, S., Rustaiyan, A., Saeidnia, S., Nikan, M., & Gohari, A. R. (2015). Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens. Pharmacognosy Research, 7(4), 314-321. https://doi.org/10.4103/0974-8490.167893

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    © 2015 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0