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Caffeoylquinic acids in leaves of selected Apocynaceae species: Their isolation and content

1, 1, 2, 3★★ Corresponding author

  1. 1School of Science, Monash University Sunway Campus, Bandar Sunway, 46150 Petaling Jaya, Selangor, Malaysia
  2. 2Natural Products Division, Forest Research Institute Malaysia, Kepong, 52109 Selangor, Malaysia
  3. 3Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia

CORRESPONDENCE

Eric Wei Chiang Chan

Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia

chanwc@ucsiuniversity.edu.my

Volume 6, Issue 1 · pp. 67-72 · 2013 · DOI: 10.4103/0974-8490.122921

ABSTRACT

Three compounds isolated from the methanol (MeOH) leaf extract of Vallaris glabra (Apocynaceae) were those of caffeoylquinic acids (CQAs). This prompted a quantitative analysis of their contents in leaves of V. glabra in comparison with those of five other Apocynaceae species (Alstonia angustiloba, Dyera costulata, Kopsia fruticosa, Nerium oleander, and Plumeria obtusa), including flowers of Lonicera japonica (Japanese honeysuckle), the commercial source of chlorogenic acid (CGA). Compound were isolated by column chromatography, and identified by NMR and MS analyses. CQA content of leaf extracts was determined using reversed-phase HPLC. From the MeOH leaf extract of V. glabra, 3-CQA, 4-CQA, and 5-CQA or CGA were isolated. Content of 5-CQA of V. glabra was two times higher than flowers of L. japonica, while 3-CQA and 4-CQA content was 16 times higher. With much higher CQA content than the commercial source, leaves of V. glabra can serve as a promising alternative source.

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    Wong, S. K., Lim, Y. Y., Ling, S. K., & Chan, E. W. C. (2013). Caffeoylquinic acids in leaves of selected Apocynaceae species: Their isolation and content. Pharmacognosy Research, 6(1), 67-72. https://doi.org/10.4103/0974-8490.122921

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0