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The efficacy of ginger added to ondansetron for preventing postoperative nausea and vomiting in ambulatory surgery

1, 2★, 3, 2, 4, 5★ Corresponding author

  1. 1Department of Pharmacology, Midnapore Medical College, Paschim Medinipur
  2. 2Departments of Anaesthesiology, College of Medicine and Sagore Dutta Hospital
  3. 3NRS Medical College
  4. 4Bangur Institute of Neurology
  5. 5I.P.G.M.E.R, Kolkata, West Bengal, India

CORRESPONDENCE

Anjan Das

Departments of Anaesthesiology, College of Medicine and Sagore Dutta Hospital

anjan2k8@yahoo.com

Volume 6, Issue 1 · pp. 52-57 · 2013 · DOI: 10.4103/0974-8490.122918

ABSTRACT

Post-operative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many costly antiemetic drugs and regimens. The study was carried out to compare the efficacy of ginger (Zingiber officinale) added to Ondansetron in preventing PONV after ambulatory surgery. It was a prospective, double blinded, and randomized controlled study. From March 2008 to July 2010, 100 adult patients of either sex, aged 20-45, of ASA physical status I and II, scheduled for day care surgery, were randomly allocated into Group A[(n = 50) receiving (IV) Ondansetron (4 mg) and two capsules of placebo] and Group B[(n = 50) receiving IV Ondansetron (4 mg) and two capsules of ginger] simultaneously one hour prior to induction of general anaesthesia (GA) in a double-blind manner. One ginger capsule contains 0.5 gm of ginger powder. Episodes of PONV were noted at 0.5h, 1h, 2h, 4h, 6h, 12h and 18h post- operatively. Statistically significant difference between groups A and B (P < 0.05), was found showing that ginger ondansetron combination was superior to plain Ondansetron as antiemetic regimen for both regarding frequency and severity. Prophylactic administration of ginger and ondansetron significantly reduced the incidence of postoperative nausea and vomiting compared to ondansetron alone in patients undergoing day care surgery under general anaesthesia.

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    Mandal, P., Das, A., Majumdar, S., Bhattacharyya, T., Mitra, T., & Kundu, R. (2013). The efficacy of ginger added to ondansetron for preventing postoperative nausea and vomiting in ambulatory surgery. Pharmacognosy Research, 6(1), 52-57. https://doi.org/10.4103/0974-8490.122918

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0