Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

Phytochemical screening and cytotoxicity studies of Chrysophyllum pruniforme Pierre ex Engl. barks

1★, 2, 1, 3, 1, 1, 3, 4★ Corresponding author

  1. 1Pharmacopea and Traditional Medicine Institute, National Center of Technological and Scientific Research
  2. 2Medical Research unit Albert Schweitzer Hospital, Lambaréné
  3. 3National Laboratory of Public Health, Libreville
  4. 4National Institute of Agronomy and Biotechnology, Franceville, Gabon

CORRESPONDENCE

Sophie Aboughe Angone

Pharmacopea and Traditional Medicine Institute, National Center of Technological and Scientific Research

sophie.aboughe@gmail.com

Volume 5, Issue 3 · pp. 195-199 · 2013 · DOI: 10.4103/0974-8490.112427

ABSTRACT

Chrysophyllum pruniforme of family sapotaceae is a plant used in traditional medicine in Gabon. In this study, C. pruniforme barks were subjected to phytochemical screening and cytotoxicity investigations. Different concentrations of aqueous and total phenolic extract were tested on mice and on human erythrocytes. Phytochemical screening of C. pruniforme barks revealed the presence of flavonoids, saponins, and tannins, reducing sugars, polyphenols and traces of anthraquinones. When tested in vitro, aqueous and the phenolic extracts showed hemolytic activities on human erythrocytes with phenolic compounds being more cytotoxic than aqueous extracts. In vivo study of toxicity, allowed to determine the LD50 at 90 mg/kg for the doses of 50, 150 and 250 mg/kg of body weight. These data indicate in one hand that C. pruniforme is rich in phenolic compounds and that the aqueous and total phenolic extracts could be considered as toxic for mice and maybe potentially toxic to humans in the other hand.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Angone, S. A., Mewono, L., Mounanga, M. B., Medzegue, S., Mendene, H. F. E., Ndong, J. M., Siawaya, J. F. D., & Souza, A. (2013). Phytochemical screening and cytotoxicity studies of Chrysophyllum pruniforme Pierre ex Engl. barks. Pharmacognosy Research, 5(3), 195-199. https://doi.org/10.4103/0974-8490.112427

    Copyright and licence

    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0