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Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents

1★, 2, 1, 3★ Corresponding author

  1. 1Departments of Physiology, Faculty of Basic Medical Sciences, College of Medicine
  2. 2Veterinary Pathology, Faculty of Veterinary Medicine
  3. 3Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria

CORRESPONDENCE

Samuel Adetunji Onasanwo

Departments of Physiology, Faculty of Basic Medical Sciences, College of Medicine

samphil2002@yahoo.com

Volume 5, Issue 3 · pp. 173-178 · 2013 · DOI: 10.4103/0974-8490.112423

ABSTRACT

This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P £ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.

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    Onasanwo, S. A., Emikpe, B. O., Ajah, A. A., & Elufioye, T. O. (2013). Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents. Pharmacognosy Research, 5(3), 173-178. https://doi.org/10.4103/0974-8490.112423

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0