Article · Volume 5, Issue 2 · pp. 55-59

New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits

Nesrin M. Fayek¹, Azza R. Abdel Monem¹, Mohamed Y. Mossa¹, Meselhy R. Meselhy¹

¹Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

Abstract

b-amyrin-3-(3'-dimethyl) butyrate, a new natural compound was isolated from the fruits of Manilkara zapota (L.) Van Royen, in addition to lupeol-3-acetate and 4-caffeoylquinic acid (cryptochlorogenic acid). The structures of these compounds were identified using different spectral methods (IR, MS, UV, 1H-NMR, 13C-NMR and 2D-NMR). The alcoholic and aqueous extracts of the unripe fruits, in addition to their aqueous homogenate exhibited antioxidant, antihyperglycemic and hypocholesterolemic activities.

Keywords: 4-caffeoylquinic acid; antihyperglycemic; antioxidant; b-amyrin-3-(3'-dimethyl) butyrate; hypocholesterolemic; lupeol-3-acetate; Manilkara zapota

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