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In vitro H+ -K+ ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.

1, 1, 2★★ Corresponding author

  1. 1Department of Pharmacology, Shri Ram Institute of Technology -Pharmacy, Jabalpur, Madhya Pradesh
  2. 2Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh, India

CORRESPONDENCE

Gopal Rai

Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh, India

drgopalrai1978@gmail.com

Volume 4, Issue 2 · pp. 123-126 · 2012 · DOI: 10.4103/0974-8490.94738

ABSTRACT

This study was undertaken to study in vitro H+-K+ ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Total phenolic and flavonoid contents from extract was quantified and H+-K+ ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract. Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.

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    Yadav, P., Ganeshpurkar, A., & Rai, G. (2012). In vitro H+ -K+ ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.. Pharmacognosy Research, 4(2), 123-126. https://doi.org/10.4103/0974-8490.94738

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    © 2012 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0