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Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats

1★, 1, 1, 1★ Corresponding author

  1. 1Department of Pharmacognosy, Medicinal Plant Research Laboratory, R.C. Patel institute of Pharmaceutical Education and Research, Shirpur - 425 405, Maharashtra, India

CORRESPONDENCE

Anil U. Tatiya

Department of Pharmacognosy, Medicinal Plant Research Laboratory, R.C. Patel institute of Pharmaceutical Education and Research, Shirpur - 425 405, Maharashtra, India

aniltatiya@rediffmail.com

Volume 4, Issue 1 · pp. 50-56 · 2011 · DOI: 10.4103/0974-8490.91040

ABSTRACT

Individually Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn. (Euphorbiaceae) and Phyllanthus emblica Linn. single plant extracts have been reported to have hepatoprotective activity. However, literature survey shows that no sufficient scientific data has been publish on pharmacological evaluation of these plants in combined form. Hepatoprotective activity of the polyherbal hepatoprotaective formulation (PHF)-containing spray-dried aqueous extracts of Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn. (Euphorbiaceae) and Phyllanthus emblica Linn. (Euphorbiaceae), was screened against paracetamol, carbon tetrachloride (CCl4), and ethanol-induced hepatic damage in rats. PHF was evaluated by measuring levels of serum marker enzymes like SGOT, SGPT, ALP, direct bilirubin (DB),and lactate dehydrogenase (LDH). The histological studies were also studied support the biochemical parameters. Silymarin was used as standard drug. Administration of PHF (100 and 200 mg/kg p.o.) significantly inhibited paracetamol, CCl4 and ethanol-induced elevation levels of SGPT, SGOT, ALP, DB and LDH. A comparative histopathological study of liver exhibited almost normal architecture as compared to toxicant group. Results suggests that the hepatoprotective effects of PHF might be useful for liver protection due to combined action of all plant extracts along with their phytoconstituents.

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    Tatiya, A. U., Surana, S. J., Sutar, M. P., & Gamit, N. H. (2011). Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats. Pharmacognosy Research, 4(1), 50-56. https://doi.org/10.4103/0974-8490.91040

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    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0