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Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats

1★, 2, 3★ Corresponding author

  1. 1Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 121
  2. 2A.R.College of Pharmacy, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120;
  3. 3Nutan Education Trust’s B. Pharmacy College, At. Rampura, Po. Kakanpur, Tal. Godhra, Dist. Panchmahal, Gujarat - 389 713, India

CORRESPONDENCE

S. H. Shukla

Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 121

shshukla@rediffmail.com

Received: 27-06-2010; Accepted: 12-01-2011.

Volume 2, Issue 6 · pp. 359-363 · 2011 · DOI: 10.4103/0974-8490.75455

ABSTRACT

In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated. Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre. Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count. This drug is found to be a potential immunostimulant.

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    Shukla, S. H., Saluja, A. K., & Pandya, S. S. (2011). Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats. Pharmacognosy Research, 2(6), 359-363. https://doi.org/10.4103/0974-8490.75455

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    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0