Article · Volume 2, Issue 2 · pp. 86-88
Diuretic activity of leaves of Plectranthus amboinicus (Lour) Spreng in male albino rats
Roshan Patel1, Naveen K. Mahobia2, Ravindra Gendle3, Basant Kaushik3, Sudarshan K. Singh4
- 1Department of Pharmacognosy, Shree Leuva Patel Trust Pharmacy Mahila College, Amreli, (Gujarat), India.
- 2Department of Pharmaceutical Chemistry, Shree Leuva Patel Trust Pharmacy Mahila College, Amreli, (Gujarat), India.
- 3Department of Pharmaceutics and Pharmacognosy, Institute of Pharmacy, RITEE, Raipur, (C.G.), India.
- 4Department of Pharmaceutics, Shree H. N. Shukla Institute of Pharmaceutical Education and Research, Rajkot, (Gujarat), India.
Abstract
The shade-dried powder of leaves of Plectranthus amboinicus (Lour) Spreng was subjected to successive extraction using the various solvents (petroleum ether, chloroform, ethanol and water) in increasing order of polarity. The preliminary phytochemical analyses were carried out for all the extracts. The analyses of the leaves revealed the presence of alkaloids, carbohydrates, glycosides, proteins, amino acids, flavonoids, quinine, tannins, phenolic compounds and terpenoids. Since the phytoconstituents present in the ethanolic and aqueous extracts were similar, both the extracts were selected for further study. The diuretic properties of ethanolic and aqueous extracts were evaluated by determination of urine volume and electrolyte concentration in male albino rats. Furosemide (10 mg/kg) was used as standard while normal saline (0.9%) was used as control. Both ethanolic and aqueous extracts (500 mg/kg) have shown significant increase in the volume of urine and urinary concentration of Na, K and Cl ions. Thus, from the is study it may be concluded that the leaves of P. amboinicus (Lour) Spreng possess diuretic activities.
Keywords: Diuretic; electrolyte concentration; Plectranthus amboinicus
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