Article · Volume 2, Issue 2 · pp. 102-106
Bronchodilator activity of aqueous extract of stem bark of Ailanthus excelsa Roxb.
Dinesh Kumar1, S. S. Bhujbal2, R. S. Deoda2, S. C. Mudgade2
- 1Rayat Institute of Pharmacy, Railmajra, S.B.S. Nagar, Punjab, India
- 2Department of Pharmacognosy, Pad. Dr. D. Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune, India.
Abstract
Biologically active compounds from natural sources are of interest as possible new drugs for infectious diseases. Ailanthus excelsa Roxb. has been used in Indian system of medicine in the treatment of asthma, bronchitis, cold, colic pain, etc. Stem bark of A. excelsa Roxb. has been used as a decoction in traditional claims. So, our traditional claims enforced us to evaluate its bronchodilator activity. We have evaluated its bronchodilator activity in milk-induced leukocytosis and eosinophilia, clonidine-induced mast cell degranulation, bronchoalveolar lavage fluid (BALF), and lung histopathology models. The aqueous extract of stem bark in doses of 100, 200, 400 mg/kg showed significant activity.
Keywords: Bronchodilator; Ailanthus excelsa Roxb.; bronchoalveolar lavage fluid
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