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PR · Lens · Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins

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Article · Volume 2, Issue 1 · pp. 10-14

Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins

M. S. Ranjith1, A. J. A. Ranjitsingh2, S. Gokul Shankar3, G. S. Vijayalaksmi4, K. Deepa5, K. Babu6, Harcharan Singh Sidhu3

  1. 1Faculty of Medicine, Microbiology Unit, AIMST University, Kedah, Malaysia.
  2. 2Department of Advanced Zoology and Biotechnology, Sri Paramakalyani College, Alwarkurichi.
  3. 3Faculty of Medicine, Microbiology Unit.
  4. 4Sri Paramakalyani Center for Environmental Sciences, M. S. University, Tirunelveli.
  5. 5Anatomy Unit, AIMST University, Kedah, Malaysia.
  6. 6R and D Center, Cholayil Private Limited, Chennai, India.

Abstract

Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1a and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.

Keywords: Histamine; immunomodulation; interleukin; mast cell; medicinal plants; Solanum trilobatum

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