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Fumaria parviflora Lam. Aqueous Extract Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized Clinical Trial

1, 2, 3, 3, 3

  1. 1Department of Pharmaceutics, Faculty of Pharmacy, Traditional Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IRAN.
  2. 2Department of Pediatrics and Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IRAN.
  3. 3Department of Pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, IRAN.

CORRESPONDENCE

Dr. Ali Mohammad Ranjbar,

[1]Department of Pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, IRAN. and [2]Department of Pharmacognosy, Traditional Pharmacy and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, IRAN.

amranjbar@alumnus.tums.ac.ir

Received: 13-08-2024; Accepted: 07-05-2025.

Volume 17, Issue 3 · pp. 867-872 · 2025 · DOI: 10.5530/pres.20251909

ABSTRACT

Infantile colic observes 10 to 40% of infants during first few months of life. The purpose of the present study was to evaluate the effectiveness of Fumaria parviflora Lam. (will fumitory) aqueous extract on infantile colic. A total of 52 breastfed infants suffering from infantile colic were randomly assigned to two groups. Will fumitory group and simethicone group received will fumitory extract and simethicone for 10 days, respectively. During the period of study, changing in infants’ colic symptoms including duration of crying, stooling frequency and consistency as well as probable side effects were inquired every day from the parents. The reduction in daily crying duration (0.05). No adverse effects related to will fumitory and simethicone group were observed. Will fumitory make a considerable improvement in colic related crying in comparison with simethicone. It was also well tolerable by infants suggesting as a new therapeutic approach in infantile colic.

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    Ramezani, V., Shadkam, M. N., Ghiasirad, M., Ebrahimi, S., & Ranjbar, A. M. (2025). Fumaria parviflora Lam. Aqueous Extract Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized Clinical Trial. Pharmacognosy Research, 17(3), 867-872. https://doi.org/10.5530/pres.20251909

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    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0