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Phyto-Analytical Studies and in vitro Wound Healing Activity of Synedrella nodiflora (L.) Gaertn Leaf Extract

1★, 1, 1, 1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, School of Pharmacy, Sri Balaji Vidyapeeth University, Pillayarkuppam, Puducherry, INDIA.

CORRESPONDENCE

Joshna Koodathil

Department of Pharmaceutical Chemistry, School of Pharmacy, Sri Balaji Vidyapeeth University, Pillayarkuppam, Puducherry, INDIA.

joshnak@sbvu.ac.in

Received: 29-08-2024; Accepted: 22-01-2025.

Volume 17, Issue 2 · pp. 519-531 · 2025 · DOI: 10.5530/pres.20251916

ABSTRACT

Traditionally among the Nigerian population Synedrella nodiflora is prominently used for treating Putrefied Wound. The present work was designed to evaluate the In vitro Wound healing activity of Synedrella nodiflora leaf extracts. The current research work was aimed to perform the Qualitative phytochemical screening, FTIR, ICP-OES, Quantitative estimation of total phenolic and flavonoid content and in vitro pharmacological assay includes Antioxidant assay, Protein denaturation assay, cell line scratch assay for wound healing of EAE and EEs of Synedrella nodiflora. Secondary phytochemicals like Flavonoid, Alkaloid, Tannin, Phenols, Terpenoids and Steroids were reported. The ICP-OES analysis concluded that the presence of elements like Zn, Fe, Cu, Mg and heavy metals like Ni, Pb, Cr and Cd were within their limits as per WHO. The EAE and EE of Synedrella nodiflora were assessed for their total phenolic and flavonoid content. The Antioxidant activity of EAE and EE showed IC50 value 2.24±0.02 mg/mL and 3.72±0.02 mg/mL compared with standard Ascorbic Acid of 42.76±0.01 µg/mL. The % Inhibition of standard Diclofenac shows IC50 value 27.99±0.026 µg/mL. whereas the IC50 values of EAE and EE were found to be 294.98±0.02 µg/mL and 138.98±0.05 µg/mL respectively. The relative cell migration of EAE and EE were 0.041±0.05 mm and 0.036±0.01 mm at 2mcg. These studies concluded that the Synedrella nodiflora leaf extracts were rich in various phytochemicals and can be used for treating wounds due to its antioxidant, anti-inflammatory and wound healing potential.

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    Koodathil, J., Ramadass, L., Jayachandran, S., & Sekar, J. (2025). Phyto-Analytical Studies and in vitro Wound Healing Activity of Synedrella nodiflora (L.) Gaertn Leaf Extract. Pharmacognosy Research, 17(2), 519-531. https://doi.org/10.5530/pres.20251916

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    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0