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Subacute Oral Toxicity Evaluation of Freeze-Dried Fruits of Lipote (Syzygium polycephaloides (C.B. Rob.) Merr.) in ICR Mice

1, 1, 2, 3, 2, 2, 2, 4, 1, 1, 3, 1, 1

  1. 1Institute of Human Nutrition and Food, College of Human Ecology, University of the Philippines Los Baños (UPLB), Laguna, PHILIPPINES.
  2. 2Department of Basic Veterinary Sciences, College of Veterinary Medicine, UPLB, Laguna, PHILIPPINES.
  3. 3Institute of Food Science and Technology, College of Agriculture and Food Science, UPLB, Laguna, PHILIPPINES.
  4. 4Institute of Molecular Biology and Biotechnology, National Institute of Health, University of the Philippines Manila, Manila, PHILIPPINES.

CORRESPONDENCE

Liezl M. Atienza

Institute of Human Nutrition and Food, College of Human Ecology, University of the Philippines Los Baños (UPLB), Laguna, PHILIPPINES.

lmatienza@up.edu.ph

Received: 06-02-2023; Accepted: 23-04-2023.

Volume 15, Issue 3 · pp. 504-513 · 2023 · DOI: 10.5530/pres.15.3.053

ABSTRACT

Background: Lipote (Syzygium polycephaloides (C.B. Rob.) Merr.) is an indigenous fruit in the Philippines with potential functions against obesity and non-communicable diseases, but limited literature was available on its safety.Objectives: This study investigated the subacute toxicity effects of freeze-dried fruits of lipote (Syzygium polycephaloides (C.B. Rob.) Merr.) on ICR mice.Materials and Methods: Ten male and ten female 6-week-old ICR mice were divided into two groups: (1) control (vehicle), and (2) lipote group, given with 2000 mg/kg body weight (BW) dose of freeze-dried lipote fruit powder reconstituted in distilled water.Results: After 28 days of oral gavage, the lipote group showed no significant changes on feed and water intake, and hematology and blood chemistry parameters were comparable with those of control group and published normal values. Body weights of all experimental animals also increased significantly (p2000 mg/kg.

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    Cayetano, A. C., Atienza, L. M., Estacio, M. A. C., Castillo-Israel, K. A. T., Desamero, M. J., Gapasin, R. P., Maniwang, J. C., Navarro, R. C., Sunico, D. J. A., Aranzado, J. R. D., Bainto-Ancheta, L. C., Delomen, J. I., & Tengco, J. M. J. (2023). Subacute Oral Toxicity Evaluation of Freeze-Dried Fruits of Lipote (Syzygium polycephaloides (C.B. Rob.) Merr.) in ICR Mice. Pharmacognosy Research, 15(3), 504-513. https://doi.org/10.5530/pres.15.3.053

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    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0