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Physiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches

1, 2, 1

  1. 1Faculty of Pharmacy, PAHER University, Udaipur, Rajasthan, INDIA.
  2. 2School of Pharmacy, Sangam University, Bhilwara, Rajasthan, INDIA.

CORRESPONDENCE

Deepika Bairagee

Faculty of Pharmacy, PAHER University, Udaipur, Rajasthan, INDIA.

bairagee.deepika@gmail.com

Received: 26-08-2022; Accepted: 09-11-2022.

Volume 15, Issue 1 · pp. 64-70 · 2022 · DOI: 10.5530/097484900244

ABSTRACT

Aim: The present research aimed to formulate a transdermal patch incorporating herbal bioactive Vitex negundo extract. The polymers that were used for selected sustained release of the drug are HPMC, PVP K30 and polyethylene glycol used as a plasticizer.Materials and Methods: Transdermal patches were prepared using the drug with two (HPMC and PVP K30) different polymers. The prepared transdermal films were evaluated for their physico-chemical characteristics such as physical appearance, weight uniformity, thickness, folding endurance, moisture content, drug content, percent moisture loss and permeation studies. The skin irritation study done on rat skin showed that the formulation does not produce irritation to the skin it showed the successful release of drug from the fabricated patch.Results: The in vitro release of formulation F1, F2, F3, F4, F5 and F6 has shown release of about 89.15%, 87.12%, 82.34%, 92.45%, 86.78% and 76.21% at 8hr. The order of drug release was found to be F4>F1>F2>F3>F6>F5.Conclusion: It could be concluded that it was concluded from the study, that the transdermal patch containing herbal bioactive Vitex negundo F4 batch showed the highest percent of drug release and other desirable properties can be developed.

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    Verma, P., Maheshwari, N., & Bairagee, D. (2022). Physiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches. Pharmacognosy Research, 15(1), 64-70. https://doi.org/10.5530/097484900244

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    © 2022 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0