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Statistical Evaluation and Characterization of Carica papaya Metabolites

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  1. 1Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, INDIA.

CORRESPONDENCE

Vidhya Meleveetil

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, INDIA.

vidhyarmenon@gmail.com

Received: 10-01-2021; Accepted: 04-05-2021.

Volume 13, Issue 3 · pp. 129-134 · 2021 · DOI: 10.5530/pres.13.3.4

ABSTRACT

Background: Natural resources are often sought for potential molecules which are pharmacologically active. Carica papaya is a well-known plant, studied for its constituent secondary metabolites and their benefits.Methods: This study focuses on identifying low molecular weight secondary metabolites form Carica papaya as potential pharmacophores, based on their structure. We determined their similarity with pharmaceutically active anti-clotting molecules using clustering method. Cheminformatic and Statistical analysis was done with data on molecular characteristics.Results: We have identified Carica papaya compounds to be pharmacologically active. In this study, we have differentiated Carica papaya compounds, through statistical analysis using clustering method, on the basis of significant molecular properties.Conclusion: Molecular similarity of secondary metabolites revealed through this study identifies, Carica papaya metabolites as a possible substitute drug and a preventive medicine against thrombosis.

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    Meleveetil, V. (2021). Statistical Evaluation and Characterization of Carica papaya Metabolites. Pharmacognosy Research, 13(3), 129-134. https://doi.org/10.5530/pres.13.3.4

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    © 2021 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0